Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.79 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.77 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.77 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.77 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.77 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | STAT1 | P42224 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.69 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30561486 | 1.00 | DYRK1A (0.79) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL6058154 | 0.90 | DYRK1A (0.77) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL18472973 | 0.88 | SMN1; SMN2 (1.00) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL798579 | 0.85 | PIK3CG (0.77) | DYRK1ASMN1; SMN2PIK3CGPIK3CARAB9A | |
| SCHEMBL7733047 | 0.85 | DYRK1A (0.70) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL6068142 | 0.84 | GSK3B (0.67) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL10170616 | 0.83 | DYRK1A (1.00) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2175580 | 0.83 | DYRK1A (1.00) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL16896959 | 0.83 | RAB9A (0.66) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL6057541 | 0.83 | NPC1 (1.00) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487498-B1 | HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND APPLICATION THEREOF | ZHANG XIAOHU (CN) | 2023-09-06 | — | — | EP | disclosed |
| US-10815226-B2 | Heteroaryl compounds as inhibitors of necrosis, composition and application thereof | ACCRO BIOSCIENCE INC. (KY) | 2020-10-27 | — | — | US | disclosed |
| US-20190284180-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (HK) | 2019-09-19 | — | — | US | disclosed |
| WO-2018017435-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE INC. (KY) | 2018-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10815226-B2 | Heteroaryl compounds as inhibitors of necrosis, composition and application thereof | LITAF, BAX, TNF | DYRK1A 4614/4885SMN1; SMN2 426/4885PIK3CG 1116/4885 |
| US-20190284180-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND APPLICATION THEREOF | LITAF, BAX, TNF | DYRK1A 4614/4885SMN1; SMN2 426/4885PIK3CG 1116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.