Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 14/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.57 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.57 |
| ▸ | STAT1 | P42224 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242000 | 0.85 | DYRK1A (0.72) | DYRK1ARAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL6218888 | 0.82 | DYRK1A (0.60) | DYRK1ARAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL13486431 | 0.82 | DYRK1A (0.67) | DYRK1ARAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL2175580 | 0.80 | DYRK1A (1.00) | DYRK1ARAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL715950 | 0.79 | DYRK1A (1.00) | DYRK1ARAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL7733047 | 0.79 | DYRK1A (0.70) | DYRK1ARAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL10170616 | 0.77 | DYRK1A (1.00) | DYRK1ARAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL4501407 | 0.76 | DYRK1A (0.71) | DYRK1ARAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL8085535 | 0.76 | DYRK1A (0.71) | DYRK1ARAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL11279344 | 0.76 | DYRK1A (1.00) | DYRK1ARAB9ANPC1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407122-B1 | NEUROPROTECTIVE AGENTS, ANTIISCHEMIC, AND HYPERGLYCEMIC AGENTS; HUNTINGTON*S, PARKINSON*S, AND ALZHEIMER*S DISEASE;AMYOTROPHIC LATERAL SCLEROSIS TREATMENT; NERVOUS SYSTEM AND BRAIN DISORDERS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-06-18 | — | — | US | disclosed |
| EP-1037890-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999028318-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |