SCHEMBL7733360

SCHEMBL7733360

CCc1ccc(OC(F)(F)c2ccc(C(F)(F)Oc3ccc(C)cc3)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 2/20 0.44
ACHE P22303 2/20 0.44
TSHR P16473 1/20 0.40
EPHX2 P34913 1/20 0.38
NR1H4 Q96RI1 1/20 0.38
ALDH1A1 P00352 1/20 0.36
CETP P11597 1/20 0.36
SLC6A4 P31645 2/20 0.35
KCNH2 Q12809 2/20 0.35
HTR2A P28223 1/20 0.35
KIF11 P52732 1/20 0.35
MAPT P10636 1/20 0.35
GRIN2B Q13224 1/20 0.35
EPHX1 P07099 1/20 0.35
HCRTR2 O43614 1/20 0.34
CYP2C19 P33261 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
GPR3 P46089 1/20 0.34
POLB P06746 1/20 0.34
TP53 P04637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14749515 0.93 TSHR (0.44) BCHEACHETSHREPHX2NR1H4
SCHEMBL7735170 0.93 TSHR (0.44) BCHEACHETSHREPHX2NR1H4
SCHEMBL7731681 0.89 TSHR (0.49) BCHEACHETSHREPHX2NR1H4
SCHEMBL7730268 0.89 TSHR (0.49) BCHEACHETSHREPHX2NR1H4
SCHEMBL13808351 0.88 MAPT (0.42) BCHEACHESLC6A4KCNH2HTR2A
SCHEMBL13808367 0.88 ACHE (0.42) BCHEACHETSHREPHX2NR1H4
SCHEMBL7729573 0.88 MAOB (0.44) TSHREPHX2NR1H4
SCHEMBL7729862 0.88 MAOB (0.44) TSHREPHX2NR1H4
SCHEMBL7730645 0.87 ACHE (0.42) BCHEACHETSHRALDH1A1SLC6A4
SCHEMBL13104749 0.87 ACHE (0.42) BCHEACHETSHRALDH1A1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed