Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.42 |
| ▸ | MASP2 | O00187 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7731163 | 1.00 | F2 (0.42) | F2MASP2MMP8PADI4PADI2 | |
| SCHEMBL21436256 | 1.00 | F2 (0.42) | F2MASP2MMP8PADI4PADI2 | |
| SCHEMBL7733101 | 0.90 | ALOX15 (0.45) | F2MASP2PADI4PADI2KCNMA1 | |
| SCHEMBL7733115 | 0.90 | ALOX15 (0.45) | F2MASP2PADI4PADI2KCNMA1 | |
| SCHEMBL7729695 | 0.90 | F2 (0.38) | F2MASP2PADI4PADI2KLKB1 | |
| SCHEMBL7728852 | 0.90 | F2 (0.38) | F2MASP2PADI4PADI2KLKB1 | |
| SCHEMBL21436585 | 0.90 | ALOX15 (0.45) | F2MASP2PADI4PADI2KCNMA1 | |
| SCHEMBL21436279 | 0.90 | F2 (0.38) | F2MASP2PADI4PADI2KLKB1 | |
| SCHEMBL7721710 | 0.90 | ALOX15 (0.45) | F2MASP2PADI4PADI2KCNMA1 | |
| SCHEMBL21436233 | 0.87 | MMP8 (0.37) | F2MASP2MMP8PADI4PADI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |