SCHEMBL7733731

SCHEMBL7733731

CCCCCCC(CC=O)CCC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.46
TSHR P16473 2/20 0.44
ADH1B P00325 2/20 0.44
ADH1C P00326 2/20 0.44
ADH1A P07327 2/20 0.44
ADH4 P08319 2/20 0.44
ADH7 P40394 2/20 0.44
FAAH O00519 2/20 0.40
TRPV1 Q8NER1 1/20 0.40
MAPT P10636 2/20 0.38
TRPA1 O75762 1/20 0.38
DDAH1 O94760 1/20 0.38
GAPDH P04406 1/20 0.38
GPR84 Q9NQS5 3/20 0.38
FDPS P14324 3/20 0.38
FFAR1 O14842 1/20 0.38
EPHX1 P07099 1/20 0.37
LCK P06239 1/20 0.36
PPARD Q03181 1/20 0.36
ZDHHC20 Q5W0Z9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9263689 1.00 LMNA (0.46) LMNATSHRADH1BADH1CADH1A
SCHEMBL3850489 1.00 LMNA (0.46) LMNATSHRADH1BADH1CADH1A
SCHEMBL3847166 1.00 LMNA (0.46) LMNATSHRADH1BADH1CADH1A
SCHEMBL3841827 1.00 LMNA (0.46) LMNATSHRADH1BADH1CADH1A
SCHEMBL2961306 1.00 LMNA (0.46) LMNATSHRADH1BADH1CADH1A
SCHEMBL276625 0.98 LMNA (0.43) LMNATSHRADH1BADH1CADH1A
SCHEMBL5076605 0.96 LMNA (0.50) LMNATSHRADH1BADH1CADH1A
SCHEMBL16023957 0.96 LMNA (0.50) LMNATSHRADH1BADH1CADH1A
SCHEMBL5075482 0.96 LMNA (0.50) LMNATSHRADH1BADH1CADH1A
SCHEMBL22465774 0.96 LMNA (0.50) LMNATSHRADH1BADH1CADH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015479-A4 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR LILLY CO ELI (US) 2002-07-24 EP disclosed
EP-0946556-A4 COMBINATORIAL PROCESS FOR PREPARING HYDROFUROQUINOLINE LIBRARIES LILLY CO ELI (US) 2001-07-04 EP disclosed
EP-1015479-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR ELI LILLY AND COMPANY (US) 2000-07-05 EP disclosed
EP-0973936-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 2000-01-26 EP disclosed
EP-0946556-A1 COMBINATORIAL PROCESS FOR PREPARING HYDROFUROQUINOLINE LIBRARIES ELI LILLY AND COMPANY (US) 1999-10-06 EP disclosed
US-5834433-A ANTITUMOR AND -CARCINOMA AGENTS; SMALL CELL LUNG AND PROSTATIC CARCINOMA; ANTIMIOTIC AND ANTISECRETORY AGENTS MERRELL PHARMACEUTICALS INC. (US) 1998-11-10 US disclosed
WO-1998046631-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed
WO-1998046786-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed
WO-1998027093-A1 COMBINATORIAL PROCESS FOR PREPARING HYDROFUROQUINOLINE LIBRARIES ELI LILLY AND COMPANY (US) 1998-06-25 WO disclosed
EP-0468497-B1 Peptide-antagonists of bombesin/GRP MERRELL PHARMA INC (US) 1997-05-28 EP disclosed
EP-0468497-A2 Peptide-antagonists of bombesin/GRP MERRELL PHARMACEUTICALS INC. (US) 1992-01-29 EP disclosed