SCHEMBL7564128

SCHEMBL7564128

O=C1c2ccc(F)cc2C(=O)N1c1ccccc1N1C(=O)c2ccc(F)cc2C1=O

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
AR P10275 4/20 0.51
ESR1 P03372 4/20 0.49
ESR2 Q92731 3/20 0.49
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
CASP3 P42574 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
ALDH1A1 P00352 2/20 0.46
APEX1 P27695 1/20 0.46
POLB P06746 1/20 0.46
RECQL P46063 1/20 0.44
HSD17B10 Q99714 1/20 0.44
GAA P10253 1/20 0.44
CASP6 P55212 1/20 0.44
DDB1 Q16531 1/20 0.44
CRBN Q96SW2 1/20 0.44
CASP1 P29466 1/20 0.44
PARK7 Q99497 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17326673 0.88 MGLL (0.47) ARESR1ESR2MEN1KMT2A
SCHEMBL8040295 0.87 NR1H3 (0.52) ARESR1ESR2MEN1KMT2A
SCHEMBL28398980 0.84 AR (0.43) ARESR1ESR2MEN1KMT2A
SCHEMBL3477804 0.83 ESR1 (0.64) ARESR1ESR2MEN1KMT2A
SCHEMBL9280483 0.83 AR (0.42) ARESR1ESR2MEN1KMT2A
SCHEMBL1734116 0.80 ESR1 (0.58) ARESR1ESR2MEN1KMT2A
SCHEMBL122221 0.80 P2RX7 (0.46) ARESR1ESR2MEN1KMT2A
SCHEMBL1735146 0.79 ESR1 (0.57) ARESR1ESR2MEN1KMT2A
SCHEMBL17104364 0.79 SMN1; SMN2 (0.47) ESR1ESR2MEN1KMT2ACASP3
SCHEMBL10626656 0.79 ESR1 (0.56) ESR1ESR2MEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1233997-A1 METHOD FOR PURIFICATION OF AROMATIC POLYETHERS GENERAL ELECTRIC COMPANY (US) 2002-08-28 EP disclosed
WO-2001021686-A1 METHOD FOR PURIFICATION OF AROMATIC POLYETHERS GENERAL ELECTRIC COMPANY (US) 2001-03-29 WO disclosed