Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.38 |
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732684 | 0.91 | GRIN2B (0.40) | CYP2D6ADRA2AHTR2AADRA1AGRIN2B | |
| SCHEMBL7732339 | 0.85 | CYP2C9 (0.49) | CYP2D6LMNARAB9ACYP3A4ALDH1A1 | |
| SCHEMBL7736139 | 0.85 | GRIN2B (0.44) | CYP2D6ADRA2AHTR2AADRA1AGRIN2B | |
| SCHEMBL7736141 | 0.82 | ALDH1A1 (0.46) | CYP2D6LMNARAB9ACYP1A2CYP3A4 | |
| SCHEMBL7733055 | 0.82 | GRIN2B (0.44) | CYP2D6ADRA2AHTR2AADRA1AGRIN2B | |
| SCHEMBL7723321 | 0.81 | DRD4 (0.46) | CYP2D6ADRA2AHTR2AADRA1AGRIN2B | |
| SCHEMBL7731629 | 0.80 | GRIN2B (0.60) | CYP2D6ADRA2AHTR2AADRA1AGRIN2B | |
| SCHEMBL8117602 | 0.75 | CYP2D6 (0.41) | CYP2D6LMNASLC6A2SLC6A4CYP3A4 | |
| SCHEMBL7731064 | 0.74 | ALDH1A1 (0.47) | CYP2D6GRIN2BGRIN1LMNARAB9A | |
| SCHEMBL7734109 | 0.71 | GRIN2B (0.54) | CYP2D6GRIN2BGRIN1SIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407122-B1 | NEUROPROTECTIVE AGENTS, ANTIISCHEMIC, AND HYPERGLYCEMIC AGENTS; HUNTINGTON*S, PARKINSON*S, AND ALZHEIMER*S DISEASE;AMYOTROPHIC LATERAL SCLEROSIS TREATMENT; NERVOUS SYSTEM AND BRAIN DISORDERS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-06-18 | — | — | US | disclosed |
| EP-1037890-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999028318-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |