Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | PDE5A | O76074 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734051 | 0.92 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| Hydrochloric Acid SCHEMBL7734781 | 0.91 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL6971404 | 0.86 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7725505 | 0.84 | PDE4A (0.49) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL8325337 | 0.83 | PDE4A (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7735174 | 0.81 | PDE5A (0.46) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL13350322 | 0.79 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7725503 | 0.78 | PDE4A (0.45) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL8324871 | 0.78 | PDE4A (0.46) | PDE4DPDE4APDE4BPDE4CNPC1 | |
| SCHEMBL6974761 | 0.77 | PDE4A (0.47) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372770-B1 | TREATING A MAMMAL SUFFERING FROM A DISEASE STATE SELECTED FROM THE GROUP CONSISTING OF ASTHMA, ALLERGIES, INFLAMMATION, DEPRESSION, DEMENTIA, ATOPIC DISEASES, RHINITIS AND DISEASE STATES ASSOCIATED WITH ABNORMALLY HIGH PHYSIOLOGICAL LEVELS OF | EURO-CELTIQUE, S.A. | 2002-04-16 | — | — | US | disclosed |