Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088381 | 0.86 | DRD2 (0.50) | DRD2DRD3MAPTHTR1AADRA1D | |
| SCHEMBL7733968 | 0.86 | DRD2 (0.50) | DRD2DRD3MAPK1HTR1AADRA1D | |
| SCHEMBL2091611 | 0.83 | DRD2 (0.52) | DRD2DRD3MAPTHTR1ADRD4 | |
| SCHEMBL8828778 | 0.83 | DRD2 (0.53) | DRD2DRD3MAPTHTR1ADRD4 | |
| SCHEMBL2097964 | 0.82 | HTR1A (0.53) | DRD2DRD3MAPTHTR1AADRA1D | |
| SCHEMBL2094204 | 0.81 | HTR1A (0.52) | DRD2DRD3MAPTHTR1AADRA1D | |
| SCHEMBL1193073 | 0.81 | DRD2 (0.75) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL24755285 | 0.80 | DRD2 (0.65) | DRD2DRD3MAPK1MAPTHTR1A | |
| SCHEMBL7605693 | 0.80 | HTR1A (0.48) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL9293656 | 0.78 | DRD2 (0.66) | DRD2DRD3HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399614-B1 | TREATING NEUROMUSCULAR DYSFUNCTION OF LOWER URINARY TRACT VIA PERIPHERAL OR CENTRAL NERVOUS SYSTEM; SEROTONIN RECEPTOR ANTAGONIST | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-06-04 | — | — | US | disclosed |