Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | S100A4 | P26447 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL181041 | 0.82 | ALDH1A1 (1.00) | ALDH1A1HPGDTSHRTDP1HTT | |
| SCHEMBL7291481 | 0.81 | ALDH1A1 (0.72) | ALDH1A1HPGDTSHRTDP1GPR35 | |
| SCHEMBL10959778 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HPGDTSHRTDP1GPR35 | |
| SCHEMBL3842149 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HPGDTSHRTDP1GPR35 | |
| SCHEMBL6130889 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HPGDTSHRTDP1GPR35 | |
| SCHEMBL10867768 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HPGDTSHRTDP1GPR35 | |
| SCHEMBL11812976 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HPGDTSHRTDP1GPR35 | |
| SCHEMBL30844575 | 0.79 | ALDH1A1 (0.48) | ALDH1A1HPGDTSHRTDP1GPR35 | |
| SCHEMBL1232315 | 0.79 | ALDH1A1 (0.48) | ALDH1A1HPGDTSHRTDP1GPR35 | |
| SCHEMBL15286182 | 0.79 | GABRA1 (0.59) | ALDH1A1HPGDTSHRTDP1GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407083-B1 | ADMINISTERING AS 7-NITROBENZISOSELENAZOLINE DERIVATIVES AS ANTITUMOR AND ANTICARCINOGENIC AGENTS | OXIS INTERNATIONAL, INC. | 2002-06-18 | — | — | US | disclosed |
| EP-0701554-B1 | NOVEL COMPOUNDS HAVING A BENZISOSELEN-AZOLINE AND -AZINE STRUCTURE, METHOD FOR PREPARING SAME AND THERAPEUTIC USES THEREOF | OXIS ISLE OF MAN LTD (GB) | 2001-06-27 | — | — | EP | disclosed |
| US-6130212-A | ANTITUMOR | OXIS INTERNATIONAL S.A. (US) | 2000-10-10 | — | — | US | disclosed |
| US-6093532-A | USING ADAPTED STORAGE MEDIUM WHICH SUPPLIES SELENIUM FOR GLUTATHIONE PEROXIDASE, A CRYOPROTECTIVE AND ANTIOXIDANT ENZYME | OXIS ISLE OF MAN, LIMITED (US) | 2000-07-25 | — | — | US | disclosed |
| US-6057310-A | TREATING LEUKEMIA, BREAST CANCER | OXIS ISLE OF MAN, LIMITED (US) | 2000-05-02 | — | — | US | disclosed |
| US-6001825-A | Use of novel organoselenium compounds as pro-oxidizing agents their methods of preparation and pharmaceutical compositions and application thereof | OXIS ISLE OF MAN, LIMITED (US) | 1999-12-14 | — | — | US | disclosed |
| US-5968920-A | INCREASE GLUTATHIONE PEROXIDASE ACTIVITY FOR REDUCING LEVELS OF PEROXIDES IN CELLS OR TISSUES | OXIS ISLE OF MAN, LIMITED (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0819682-A1 | Use of novel organoselenium compounds as pro-oxidizing agents, their methods of preparation and pharmaceutical compositions and application containing them | Oxis International S.A. (FR) | 1998-01-21 | — | — | EP | disclosed |
| EP-0701554-A1 | NOVEL COMPOUNDS HAVING A BENZISOSELEN-AZOLINE AND -AZINE STRUCTURE, METHOD FOR PREPARING SAME AND THERAPEUTIC USES THEREOF | OXIS INTERNATIONAL S.A. (FR) | 1996-03-20 | — | — | EP | disclosed |
| WO-1995027706-A1 | NOVEL COMPOUNDS HAVING A BENZISOSELEN-AZOLINE AND -AZINE STRUCTURE, METHOD FOR PREPARING SAME AND THERAPEUTIC USES THEREOF | OXIS INTERNATIONAL S.A. (FR) | 1995-10-19 | — | — | WO | disclosed |