Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734165 | 0.84 | MEN1 (0.49) | KCNH2HRH3GRIN1GRIN2BOPRM1 | |
| SCHEMBL7733553 | 0.82 | KDM4E (0.52) | KCNH2HRH3OPRM1POLBMEN1 | |
| SCHEMBL7732681 | 0.78 | MEN1 (0.46) | KCNH2HRH3GRIN1GRIN2BMEN1 | |
| SCHEMBL7734147 | 0.72 | CCR3 (0.49) | KCNH2GRIN1GRIN2BCCR3MEN1 | |
| SCHEMBL10735474 | 0.71 | GRIN2B (0.73) | KCNH2HRH3GRIN1GRIN2BOPRM1 | |
| SCHEMBL5165726 | 0.71 | FAAH (0.60) | POLBMEN1KMT2A | |
| SCHEMBL8132329 | 0.70 | MEN1 (0.53) | KCNH2HRH3GRIN1GRIN2BOPRM1 | |
| SCHEMBL7732623 | 0.69 | HTT (0.54) | KCNH2HRH3MEN1KMT2A | |
| SCHEMBL7734180 | 0.69 | GRIN2B (0.80) | KCNH2GRIN1GRIN2B | |
| SCHEMBL7238944 | 0.68 | CA12 (0.73) | CCR3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407122-B1 | NEUROPROTECTIVE AGENTS, ANTIISCHEMIC, AND HYPERGLYCEMIC AGENTS; HUNTINGTON*S, PARKINSON*S, AND ALZHEIMER*S DISEASE;AMYOTROPHIC LATERAL SCLEROSIS TREATMENT; NERVOUS SYSTEM AND BRAIN DISORDERS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-06-18 | — | — | US | disclosed |
| EP-1037890-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999028318-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |