SCHEMBL7734186

SCHEMBL7734186

CCC12C(=O)CCC1C2C(=O)O

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 1/20 0.32
MEN1 O00255 1/20 0.31
POLB P06746 1/20 0.31
KMT2A Q03164 1/20 0.31
CYP19A1 P11511 4/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1087793 1.00 HSD17B1 (0.32) HSD17B1MEN1POLBKMT2ACYP19A1
SCHEMBL7733048 1.00 HSD17B1 (0.32) HSD17B1MEN1POLBKMT2ACYP19A1
SCHEMBL7733030 1.00 HSD17B1 (0.32) HSD17B1MEN1POLBKMT2ACYP19A1
SCHEMBL7737030 0.86 MEN1 (0.38) MEN1POLBKMT2ACYP19A1
SCHEMBL7735247 0.83 MEN1 (0.39) HSD17B1MEN1POLBKMT2ACYP19A1
SCHEMBL7733008 0.82 MEN1 (0.39) MEN1POLBKMT2ACYP19A1
SCHEMBL7733024 0.82 MEN1 (0.39) MEN1POLBKMT2ACYP19A1
SCHEMBL7734509 0.81 ACE (0.33) MEN1POLBKMT2A
SCHEMBL7733945 0.81
SCHEMBL7734459 0.81 HSD17B3 (0.40) MEN1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407284-B1 CONTACTING WITH ENZYME; HYDROLYSIS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-06-18 US disclosed
EP-0776201-B1 Treating anxiety LILLY CO ELI (US) 2001-10-17 EP disclosed
EP-0776200-A4 COMPOSITION AND METHOD FOR PROTECTION AGAINST DRUG DEPENDENCY LILLY CO ELI (US) 2001-01-17 EP disclosed
EP-0776201-A4 COMPOSITION AND METHOD FOR TREATING ANXIETY LILLY CO ELI (US) 1999-07-07 EP disclosed
US-5661184-A ADMINISTERING AN AGONIST TO TREAT BENZODIAZEPINE DRUG ABUSE, DRUG DEPENDENCE ELI LILLY AND COMPANY (US) 1997-08-26 US disclosed
EP-0776200-A1 COMPOSITION AND METHOD FOR PROTECTION AGAINST DRUG DEPENDENCY ELI LILLY AND COMPANY (US) 1997-06-04 EP disclosed
EP-0776201-A1 COMPOSITION AND METHOD FOR TREATING ANXIETY ELI LILLY AND COMPANY (US) 1997-06-04 EP disclosed
EP-0774454-A1 Excitatory amino acid receptor antagonists ELI LILLY AND COMPANY (US) 1997-05-21 EP disclosed
WO-1996004901-A1 COMPOSITION AND METHOD FOR TREATING ANXIETY ELI LILLY AND COMPANY (US) 1996-02-22 WO disclosed
WO-1996004900-A1 COMPOSITION AND METHOD FOR PROTECTION AGAINST DRUG DEPENDENCY ELI LILLY AND COMPANY (US) 1996-02-22 WO disclosed