Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PNLIP | P16233 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785861 | 0.90 | CTNNB1 (0.44) | CYP11B1CYP11B2TLR7MGLLTDP1 | |
| SCHEMBL249223 | 0.87 | KCNK3 (0.49) | CYP11B1CYP11B2MGLLPNLIPHSD11B1 | |
| SCHEMBL162647 | 0.84 | EPHX2 (0.53) | TLR7MGLLTRPV1NPC1RAB9A | |
| SCHEMBL10918711 | 0.83 | CYP11B1 (0.51) | CYP11B1CYP11B2TLR7MGLLTDP1 | |
| SCHEMBL18281342 | 0.80 | KCNK3 (0.44) | CYP11B1CYP11B2MGLLPNLIPHSD11B1 | |
| SCHEMBL22815931 | 0.79 | AURKA (0.54) | TLR7TRPV1NPC1RAB9AEPHX2 | |
| SCHEMBL27193291 | 0.76 | PYGL (0.40) | MGLLHSD11B1TRPV1RXRARXRB | |
| SCHEMBL6793681 | 0.76 | SERPINE1 (0.47) | CYP11B1CYP11B2TLR7TDP1TRPV1 | |
| SCHEMBL7487348 | 0.75 | KMT2A (0.46) | CYP11B1CYP11B2TLR7TDP1TRPV1 | |
| SCHEMBL20561089 | 0.74 | KCNK3 (0.49) | CYP11B1CYP11B2MGLLPNLIPHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015479-A4 | COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR | LILLY CO ELI (US) | 2002-07-24 | — | — | EP | disclosed |
| EP-1015479-A1 | COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR | ELI LILLY AND COMPANY (US) | 2000-07-05 | — | — | EP | disclosed |
| WO-1998046631-A1 | COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR | ELI LILLY AND COMPANY (US) | 1998-10-22 | — | — | WO | disclosed |