SCHEMBL162647

SCHEMBL162647

O=C(Cl)c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 3/20 0.53
TRPV1 Q8NER1 7/20 0.51
TLR7 Q9NYK1 1/20 0.49
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
FAAH O00519 1/20 0.49
HDAC3 O15379 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC2 Q92769 1/20 0.46
AURKA O14965 1/20 0.46
TPX2 Q9ULW0 1/20 0.46
NR1H4 Q96RI1 1/20 0.45
MGLL Q99685 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22815931 0.94 AURKA (0.54) EPHX2TRPV1TLR7NPC1RAB9A
SCHEMBL10910722 0.86 ALDH1A1 (0.47) EPHX2TRPV1TLR7NPC1RAB9A
SCHEMBL8593002 0.85 GRM4 (0.52) EPHX2TRPV1TLR7NPC1RAB9A
SCHEMBL9870992 0.84 ALDH1A1 (0.41) EPHX2TRPV1TLR7NPC1RAB9A
SCHEMBL7734432 0.84 CYP11B1 (0.45) EPHX2TRPV1TLR7NPC1RAB9A
SCHEMBL20015846 0.83 EPHX2 (0.57) EPHX2TRPV1TLR7NPC1RAB9A
SCHEMBL4475347 0.83 NPC1 (0.60) EPHX2TRPV1TLR7NPC1RAB9A
SCHEMBL2366475 0.82 ALDH1A1 (0.56) EPHX2TRPV1TLR7NPC1RAB9A
SCHEMBL9172265 0.82 ALDH1A1 (0.40) EPHX2TRPV1TLR7NPC1RAB9A
SCHEMBL1505766 0.82 ALDH1A1 (0.40) EPHX2TRPV1TLR7NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1211 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112047917-A Xanthohumol derivative and preparation method and application thereof 中国科学院新疆理化技术研究所 2020-12-08 CN claimed
CN-122010796-A Small molecule inhibitor based on lactate dehydrogenase targeting design and application thereof 南京师范大学 2026-05-12 CN disclosed
EP-4713018-A1 TRANSFECTION COMPOSITIONS SUITABLE FOR PRODUCING A BIOLOGICAL PRODUCT PolyPlus Transfection (FR) 2026-03-25 EP disclosed
US-20260062397-A1 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS ATUX ISKAY LLC (US) 2026-03-05 US disclosed
EP-4692071-A1 PHOTOCHROMIC COMPOUND, NAPHTHOL DERIVATIVE, CURABLE COMPOSITION, OPTICAL ARTICLE, LENS, AND EYEGLASS TOKUYAMA CORPORATION (JP) 2026-02-11 EP disclosed
EP-4692072-A1 PHOTOCHROMIC COMPOUND, PROPARGYL ALCOHOL COMPOUND, CURABLE COMPOSITION, OPTICAL ARTICLE, LENS, AND SPECTACLES TOKUYAMA CORPORATION (JP) 2026-02-11 EP disclosed
US-20260022098-A1 BULLEYACONITINE A DERIVATIVE WITH ANALGESIC ACTIVITY, AND PREPARATION METHOD AND APPLICATION THEREOF UNIV SOUTHWEST JIAOTONG (CN) 2026-01-22 US disclosed
US-12528800-B2 Pesticidal compounds BASF SE (DE) 2026-01-20 US disclosed
US-12522575-B2 2-diarylmethyl-4-aminotetrahydropyran derivatives and related compounds as anticancer, antiinflammatory, antifibrotic and neuroprotective agents ATUX ISKAY LLC (US) 2026-01-13 US disclosed
US-20250376455-A1 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS ATUX ISKAY LLC (US) 2025-12-11 US disclosed
US-4117143-A USED AS ANTITHROMBOTIC AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1978-09-26 US disclosed
US-4113957-A DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC BAYER AKTIENGESELLSCHAFT (DE) 1978-09-12 US disclosed
US-4113872-A DIURETICS, SALURETICS, ANTIHYPERTENSIVE, ANTITHROMBOTIC AGENTS BAKER AKTIENGESELLSHAFT (DE) 1978-09-12 US disclosed
US-4112109-A DIURETIC, SALURETIC, ANTIHYPERTENSIVE, ANTITHROMBOTIC BAYER AKTIENGESELLSCHAFT (DE) 1978-09-05 US disclosed
US-4099011-A DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC BAYER AKTIENGESELLSCHAFT (DE) 1978-07-04 US disclosed
US-4096152-A DIURETICS, SALURETICS, HYPOTENSIVE BAYER AKTIENGESELLSCHAFT (DT) 1978-06-20 US disclosed
US-4069334-A DIURETICS, HYPOTENSIVES BAYER AKTIENGESELLSCHAFT (DT) 1978-01-17 US disclosed
US-4009208-A N,N'-HEPTAMETHYLENEBIS(4-METHOXYBENZAMIDE) STERLING DRUG INC. (US) 1977-02-22 US disclosed
US-4002641-A DIURETICS, SALURETICS, HYPOTENSIVES BAYER AKTIENGESELLSCHAFT (DT) 1977-01-11 US disclosed
US-3960945-A 4-[-(Alkoxy or polyhaloalkoxy)-benzamido]cyclohexanones STERLING DRUG INC. (US) 1976-06-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260022098-A1 BULLEYACONITINE A DERIVATIVE WITH ANALGESIC ACTIVITY, AND PREPARATION METHOD AND APPLICATION THEREOF OPRD1, OPRM1, OPRK1 EPHX2 1179/4885TRPV1 26/4885TLR7 325/4885
US-12528800-B2 Pesticidal compounds CBR1, CBR3, SCN1B EPHX2 1859/4885TRPV1 1692/4885TLR7 3373/4885
US-20250376455-A1 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS MYC, MYCBP, MYCBP2 EPHX2 4765/4885TRPV1 4044/4885TLR7 3189/4885
US-20260062397-A1 2-DIARYLMETHYL-4-AMINOTETRAHYDROPYRAN DERIVATIVES AND RELATED COMPOUNDS AS ANTICANCER, ANTIINFLAMMATORY, ANTIFIBROTIC AND NEUROPROTECTIVE AGENTS MYC, MYCBP, FOXO1 EPHX2 4799/4885TRPV1 3125/4885TLR7 3559/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.