Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.46 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610401 | 0.89 | HTR1A (0.56) | LMNAHTR1AADRA1ADRD4ADRA1B | |
| SCHEMBL7612650 | 0.88 | HTR1A (0.48) | LMNAHTR1AADRA1ADRD4ADRA1B | |
| SCHEMBL7611665 | 0.88 | HTR1A (0.54) | LMNAHTR1AADRA1ADRD4ADRA1B | |
| SCHEMBL7610548 | 0.84 | HTR1A (0.55) | LMNAHTR1AADRA1ADRD4ADRA1B | |
| SCHEMBL7606620 | 0.84 | HTR1A (0.54) | LMNAGAAHTR1AADRA1ADRD4 | |
| SCHEMBL7612647 | 0.83 | HTR1A (0.61) | LMNAHTR1AADRA1ADRD4ADRA1B | |
| SCHEMBL6933606 | 0.80 | HTR1A (0.70) | LMNAHTR1AADRA1ADRD4ADRA1B | |
| SCHEMBL7612669 | 0.79 | HTR1A (0.59) | LMNAHTR1AADRA1ADRD4ADRA1B | |
| SCHEMBL7613929 | 0.79 | ADRA1A (0.53) | LMNAHTR1AADRA1ADRD4ADRA1B | |
| SCHEMBL7613420 | 0.79 | HTR1A (0.59) | LMNAHTR1AADRA1ADRD4ADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399614-B1 | TREATING NEUROMUSCULAR DYSFUNCTION OF LOWER URINARY TRACT VIA PERIPHERAL OR CENTRAL NERVOUS SYSTEM; SEROTONIN RECEPTOR ANTAGONIST | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-06-04 | — | — | US | disclosed |