Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.54 |
| ▸ | MARS1 | P56192 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3948221 | 0.89 | PTGS2 (0.57) | PTGS2PTGS1MARS1JAK2PTK2 | |
| SCHEMBL395735 | 0.84 | MARS1 (0.43) | PTGS2PTGS1MARS1SLC16A3 | |
| SCHEMBL3946879 | 0.81 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL3938737 | 0.79 | MEN1 (0.57) | PTGS2PTGS1 | |
| SCHEMBL396392 | 0.79 | MEN1 (0.43) | — | |
| SCHEMBL3939882 | 0.77 | MARS1 (0.46) | PTGS2PTGS1MARS1SLC16A3 | |
| SCHEMBL5577174 | 0.76 | MARS1 (0.45) | PTGS2PTGS1MARS1SLC16A3 | |
| SCHEMBL393900 | 0.74 | MARS1 (0.47) | PTGS2PTGS1MARS1SLC16A3 | |
| SCHEMBL3945552 | 0.73 | MEN1 (0.44) | MARS1SLC16A3 | |
| SCHEMBL3940435 | 0.73 | PTGS2 (0.61) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6348468-B1 | THESE COMPOUNDS HAVE EXCELLENT INHIBITORY ACTIVITY AGAINST INTERLEUKIN-1.BETA. PRODUCTION, IMMUNE SYSTEM DISEASES, INFLAMMATORY DISEASES, ISCHEMIC DISEASES AND THE LIKE. | KOWA CO., LTD. (JP) | 2002-02-19 | — | — | US | claimed |