Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383618 | 1.00 | GSK3B (0.62) | GSK3BKMT2AL3MBTL1TDP1LMNA | |
| SCHEMBL11277802 | 0.94 | GSK3B (0.64) | GSK3BKMT2ALMNAHSD17B3THRA | |
| SCHEMBL8402203 | 0.92 | KMT2A (0.67) | GSK3BKMT2AL3MBTL1TDP1LMNA | |
| SCHEMBL9419411 | 0.90 | KMT2A (0.69) | GSK3BKMT2AL3MBTL1TDP1LMNA | |
| SCHEMBL15199328 | 0.86 | GSK3B (0.69) | GSK3BKMT2ALMNAMAPTTHRA | |
| SCHEMBL8510520 | 0.85 | HSD17B3 (0.73) | GSK3BKMT2AL3MBTL1TDP1LMNA | |
| SCHEMBL9352247 | 0.85 | KMT2A (0.75) | GSK3BKMT2AL3MBTL1TDP1LMNA | |
| SCHEMBL9356308 | 0.85 | KMT2A (0.75) | GSK3BKMT2AL3MBTL1TDP1LMNA | |
| SCHEMBL2082766 | 0.85 | HSD17B3 (0.73) | GSK3BKMT2AL3MBTL1TDP1LMNA | |
| SCHEMBL9352262 | 0.85 | KMT2A (0.75) | GSK3BKMT2AL3MBTL1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417192-B1 | DRUGS WITH PYRIMIDONE COMPOUNDS INHIBITORS OF THE ENZYME LDL PLA.SUB.2 AND THEREFORE OF USE IN TREATING ATHEROSCLEROSIS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-09 | — | — | US | disclosed |