Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 13/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008519 | 0.88 | KDM4E (0.46) | PLA2G7PDE3BPDE3AMEN1KMT2A | |
| SCHEMBL7009316 | 0.88 | PLA2G7 (0.51) | PLA2G7 | |
| SCHEMBL7013431 | 0.88 | PLA2G7 (0.54) | PLA2G7 | |
| SCHEMBL7005556 | 0.88 | PLA2G7 (0.43) | PLA2G7PKM | |
| SCHEMBL7013517 | 0.83 | PKM (0.45) | PLA2G7MEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7010694 | 0.80 | RECQL (0.42) | PLA2G7PDE3BPDE3AMEN1KMT2A | |
| SCHEMBL7013475 | 0.80 | PLA2G7 (0.39) | PLA2G7 | |
| SCHEMBL7014269 | 0.79 | PLA2G7 (0.46) | PLA2G7 | |
| SCHEMBL7014929 | 0.78 | PLA2G7 (0.56) | PLA2G7MEN1PKMKMT2A | |
| SCHEMBL7011951 | 0.78 | PLA2G7 (0.56) | PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417192-B1 | DRUGS WITH PYRIMIDONE COMPOUNDS INHIBITORS OF THE ENZYME LDL PLA.SUB.2 AND THEREFORE OF USE IN TREATING ATHEROSCLEROSIS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-09 | — | — | US | disclosed |