Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | S100A4 | P26447 | 2/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6925259 | 1.00 | LMNA (0.52) | LMNAS100A4PTPRCTNFKDM4E | |
| SCHEMBL6925120 | 1.00 | LMNA (0.52) | LMNAS100A4PTPRCTNFKDM4E | |
| SCHEMBL31259816 | 0.84 | LMNA (0.55) | LMNAS100A4PTPRCTNFKDM4E | |
| SCHEMBL11755401 | 0.84 | LMNA (0.55) | LMNAS100A4PTPRCTNFKDM4E | |
| SCHEMBL6693216 | 0.82 | TNF (0.48) | LMNAS100A4PTPRCTNFKDM4E | |
| SCHEMBL19359510 | 0.81 | KMT2A (0.50) | LMNAS100A4PTPRCTNFKDM4E | |
| SCHEMBL23513454 | 0.78 | TNF (0.50) | LMNAS100A4PTPRCTNFKDM4E | |
| SCHEMBL11307307 | 0.77 | TNF (0.49) | LMNAS100A4PTPRCTNFKDM4E | |
| SCHEMBL19359440 | 0.77 | TNF (0.49) | LMNAS100A4PTPRCTNFKDM4E | |
| SCHEMBL19359528 | 0.77 | TNF (0.52) | LMNAS100A4PTPRCTNFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6429212-B1 | AMINOPEPTIDASE N INHIBITOR USED TO TREAT CANCER, TUMORS, AND RETINOPATHY; FEW SIDE EFFECTS; ANGIOGENESIS INHIBITOR | ISHIHARA SANGYO KAISHA LTD. (JP) | 2002-08-06 | — | — | US | disclosed |