Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4837910 | 0.78 | DPP4 (0.45) | DPP4TSHRF2TRPA1HTR2A | |
| SCHEMBL1452755 | 0.75 | MIF (0.46) | DPP4TSHRF2TAAR1CYP2D6 | |
| SCHEMBL8668751 | 0.75 | TSHR (0.58) | TSHRCYP2D6SRCLMNAMAPK1 | |
| SCHEMBL2106150 | 0.73 | TSHR (0.41) | DPP4TSHRF2TRPA1HTR2A | |
| SCHEMBL6250857 | 0.73 | DPP4 (0.41) | DPP4TSHRF2TRPA1HTR2A | |
| SCHEMBL158475 | 0.73 | SRC (0.42) | DPP4TSHRF2TRPA1HTR2A | |
| SCHEMBL181005 | 0.73 | TSHR (0.56) | DPP4TSHRF2TRPA1LMNA | |
| SCHEMBL2541154 | 0.73 | DPP4 (0.41) | DPP4TSHRF2TRPA1HTR2A | |
| SCHEMBL20656718 | 0.73 | MIF (0.44) | DPP4TSHRF2TRPA1HTR2A | |
| SCHEMBL18245105 | 0.71 | MIF (0.39) | DPP4TSHRF2TAAR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112538084-B | Novel KRAS G12C protein inhibitor and preparation method and application thereof | 信达生物制药(苏州)有限公司 | 2023-06-20 | — | — | CN | disclosed |
| CN-112430234-B | Novel KRAS G12C protein inhibitor and preparation method and application thereof | 信达生物制药(苏州)有限公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-112292374-B | Novel phosphoinositide 3-kinase inhibitor and preparation method and application thereof | 信达生物制药(苏州)有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-113195492-B | Novel compound with three-fused ring structure, preparation method and application thereof | 信达生物制药(苏州)有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-113195492-A | Novel compound with three-fused ring structure, preparation method and application thereof | 信达生物制药(苏州)有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-112538084-A | Novel KRAS G12C protein inhibitor and preparation method and application thereof | 信达生物制药(苏州)有限公司 | 2021-03-23 | — | — | CN | disclosed |
| CN-112430234-A | Novel KRAS G12C protein inhibitor and preparation method and application thereof | 信达生物制药(苏州)有限公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-112292374-A | Novel phosphoinositide 3-kinase inhibitor and preparation method and application thereof | 信达生物制药(苏州)有限公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-110684048-A | Novel phosphoinositide 3-kinase inhibitor and preparation method and application thereof | 信达生物制药(苏州)有限公司 | 2020-01-14 | — | — | CN | disclosed |
| US-6407096-B1 | 1,4-BENZOTHIAZINE AND 1,4-BENZOXAZINE DERIVATIVES; HYPOTENSIVE, ANTIISCHEMIC, ANTIALLERGEN, ANTIASTHMATIC AND ANTICOAGULANT AGENTS; CARDIOVASCULAR DISORDERS | TORAY INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| US-6323235-B1 | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS | OHTAKE ATSUSHI (JP) | 2001-11-27 | — | — | US | disclosed |
| EP-1028113-A1 | FUSED BENZENE HETEROCYCLE DERIVATIVES AND UTILIZATION THEREOF | TORAY INDUSTRIES, INC. (JP) | 2000-08-16 | — | — | EP | disclosed |
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |