Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6069562 | 0.92 | CHRNB2 (0.41) | TSHRDPP4F2TRPA1TAAR1 | |
| SCHEMBL11408107 | 0.87 | IDO1 (0.36) | TSHRDPP4F2TRPA1HTR2A | |
| SCHEMBL7493934 | 0.86 | IDO1 (0.48) | TSHRALDH1A1L3MBTL1CYP2D6 | |
| SCHEMBL5324736 | 0.86 | LMNA (0.50) | ALDH1A1HTTNPSR1 | |
| SCHEMBL5174129 | 0.81 | PBRM1 (0.54) | TSHRTRPA1ALDH1A1L3MBTL1GAA | |
| SCHEMBL28385338 | 0.78 | DPP4 (0.38) | TSHRDPP4F2TRPA1HTR2A | |
| SCHEMBL11272528 | 0.78 | CYP2C19 (0.42) | TSHRALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL6869750 | 0.78 | ACP3 (0.44) | TSHRHTR2AALDH1A1CYP2D6GAA | |
| SCHEMBL11663962 | 0.77 | DPP4 (0.41) | TSHRDPP4F2TRPA1HTR2A | |
| SCHEMBL4837910 | 0.75 | DPP4 (0.45) | TSHRDPP4F2TRPA1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294699-B1 | MODULATORS OF TNF- ALPHA SIGNALLING | GENZYME CORP (US) | 2016-04-13 | — | — | EP | claimed |
| EP-2326651-B1 | BUPRENORPHINE ANALOGS | PURDUE PHARMA LP (US) | 2013-11-27 | — | — | EP | claimed |
| EP-1482931-B1 | MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE | TRANSTECH PHARMA INC (US) | 2011-10-19 | — | — | EP | claimed |
| EP-1114061-B1 | FACTOR VIIa INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-03-10 | — | — | EP | claimed |
| EP-1975164-B1 | Octahydrobenzimidazolone compounds as analgetics | EURO CELTIQUE SA (LU) | 2010-01-27 | — | — | EP | claimed |
| EP-1379246-B1 | NOCICEPTIN ANALOGS | EURO CELTIQUE SA (LU) | 2008-10-08 | — | — | EP | claimed |
| EP-1385515-B1 | SPIROPYRAZOLE COMPOUNDS | EURO CELTIQUE SA (LU) | 2008-08-06 | — | — | EP | claimed |
| EP-1338604-B9 | N-ALKYLGLYCINE TRIMERES CAPABLE OF PROTECTING NEURONS AGAINST EXCITOTOXIC AGGRESSIONS AND COMPOSITIONS CONTAINING SAID TRIMERES | DIVERDRUGS SL (ES) | 2008-07-09 | — | — | EP | claimed |
| EP-1448571-B1 | HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE MONOFUNCTIONAL MACROMONOMERS | BAUSCH & LOMB (US) | 2008-05-21 | — | — | EP | claimed |
| EP-1626043-B1 | Heterocyclic thioesters | MGI GP INC (US) | 2007-12-12 | — | — | EP | claimed |
| WO-2003055867-A1 | BIPHENYLMETHYL-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE AS PPAR-GAMMA ACTIVATORS | GALDERMA RESEARCH & DEVELOPMENT, SNC (FR) | 2003-07-10 | — | — | WO | claimed |
| EP-0682663-B1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | UPJOHN CO (US) | 2001-04-18 | — | — | EP | claimed |
| EP-0736012-B1 | ANELLATED DIHYDROPYRIDINES AND THEIR USE IN THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS | BOEHRINGER INGELHEIM PHARMA (DE) | 2000-11-22 | — | — | EP | claimed |
| EP-0769006-B1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2000-11-08 | — | — | EP | claimed |
| EP-0642530-B1 | DERIVATIVES OF DOLASTATIN | BASF AG (DE) | 1998-08-12 | — | — | EP | claimed |
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | claimed |
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | claimed |
| EP-0370320-B1 | LACTAMIMIDES IN THE TREATMENT OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-30 | — | — | EP | claimed |
| EP-0223744-B1 | FLAVONE DERIVATIVES | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1992-03-11 | — | — | EP | claimed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | claimed |