Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGIR | P43119 | 7/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962770 | 0.91 | MEN1 (0.43) | HRH3MEN1KMT2ASMN1; SMN2PTGIR | |
| SCHEMBL7736464 | 0.82 | PTGIR (0.46) | HRH3HDAC1HDAC6PTGIR | |
| SCHEMBL7737680 | 0.81 | PTGIR (0.46) | HRH3HDAC1HDAC6PTGIRALDH1A1 | |
| SCHEMBL7730044 | 0.80 | PTGIR (0.48) | HRH3HDAC1HDAC6PTGIRALDH1A1 | |
| SCHEMBL7737197 | 0.80 | PTGIR (0.45) | HRH3PTGIRALDH1A1PTGDR2 | |
| SCHEMBL7737231 | 0.79 | PTGIR (0.56) | HRH3PTGIR | |
| SCHEMBL7737314 | 0.79 | PTGIR (0.44) | HRH3MEN1KMT2APTGIRALDH1A1 | |
| SCHEMBL7737683 | 0.79 | HRH3 (0.43) | HRH3PTGIRALDH1A1 | |
| SCHEMBL7736474 | 0.79 | PPARD (0.44) | HRH3HDAC1HDAC6MEN1KMT2A | |
| SCHEMBL7739657 | 0.78 | HRH3 (0.45) | HRH3HDAC1HDAC6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407096-B1 | 1,4-BENZOTHIAZINE AND 1,4-BENZOXAZINE DERIVATIVES; HYPOTENSIVE, ANTIISCHEMIC, ANTIALLERGEN, ANTIASTHMATIC AND ANTICOAGULANT AGENTS; CARDIOVASCULAR DISORDERS | TORAY INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1028113-A1 | FUSED BENZENE HETEROCYCLE DERIVATIVES AND UTILIZATION THEREOF | TORAY INDUSTRIES, INC. (JP) | 2000-08-16 | — | — | EP | disclosed |