⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2073886 | 0.81 | KCNA4 (0.31) | — | |
| SCHEMBL10412000 | 0.78 | — | — | |
| SCHEMBL624962 | 0.72 | FFAR3 (0.37) | — | |
| SCHEMBL2005167 | 0.71 | FFAR3 (0.36) | — | |
| SCHEMBL31443223 | 0.66 | CYP3A4 (0.40) | — | |
| SCHEMBL19516511 | 0.65 | — | — | |
| SCHEMBL1684992 | 0.60 | — | — | |
| SCHEMBL10388688 | 0.60 | — | — | |
| SCHEMBL181358 | 0.59 | CYP4F2 (0.30) | — | |
| SCHEMBL3103794 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258299-B2 | Process for preparation of temsirolimus | Chungwa Chemical Synthesis & Biotech Co., Ltd. (TW) | 2012-09-04 | — | — | US | disclosed |
| US-8258299-B2 | Process for preparation of temsirolimus | Chungwa Chemical Synthesis & Biotech Co., Ltd. (TW) | 2012-09-04 | — | — | US | disclosed |
| US-20100249415-A1 | Process for preparation of temsirolimus | CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO., LTD. (TW) | 2010-09-30 | — | — | US | disclosed |
| US-20100249415-A1 | Process for preparation of temsirolimus | CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO., LTD. (TW) | 2010-09-30 | — | — | US | disclosed |
| US-7202256-B2 | Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779 | WYETH (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202256-B2 | Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779 | WYETH (US) | 2007-04-10 | — | — | US | disclosed |