Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA4 | P22459 | 1/20 | 0.31 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.31 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7737182 | 0.81 | — | — | |
| SCHEMBL10412000 | 0.81 | — | — | |
| SCHEMBL23868130 | 0.75 | HSD17B10 (0.42) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL624962 | 0.75 | FFAR3 (0.37) | — | |
| SCHEMBL2005167 | 0.73 | FFAR3 (0.36) | — | |
| SCHEMBL21264369 | 0.73 | KCNA4 (0.31) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL19516511 | 0.72 | — | — | |
| SCHEMBL14713396 | 0.70 | ALDH1A1 (0.33) | — | |
| SCHEMBL21033826 | 0.69 | TSHR (0.41) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL26830530 | 0.69 | ATM (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856129-B1 | 39-DESMETHOXY DERIVATIVES OF RAPAMYCIN | BIOTICA TECH LTD (GB) | 2014-10-15 | — | — | EP | disclosed |
| US-8258299-B2 | Process for preparation of temsirolimus | Chungwa Chemical Synthesis & Biotech Co., Ltd. (TW) | 2012-09-04 | — | — | US | disclosed |
| US-8258299-B2 | Process for preparation of temsirolimus | Chungwa Chemical Synthesis & Biotech Co., Ltd. (TW) | 2012-09-04 | — | — | US | disclosed |
| US-8008318-B2 | 39-desmethoxy derivatives of rapamycin | BIOTICA TECHNOLOGY LIMITED (GB) | 2011-08-30 | — | — | US | disclosed |
| US-7897608-B2 | 39-desmethoxy-39-methyl derivatives of rapamycin | BIOTICA TECHNOLOGY LIMITED (GB) | 2011-03-01 | — | — | US | disclosed |
| US-20100249415-A1 | Process for preparation of temsirolimus | CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO., LTD. (TW) | 2010-09-30 | — | — | US | disclosed |
| US-20100249415-A1 | Process for preparation of temsirolimus | CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO., LTD. (TW) | 2010-09-30 | — | — | US | disclosed |
| US-20100081682-A1 | 39-Desmethoxy Derivatives of Rapamycin | BIOTICA TECHNOLOGY LIMITED (GB) | 2010-04-01 | — | — | US | disclosed |
| US-7648996-B2 | 39-desmethoxy derivatives of rapamycin | BIOTICA TECHNOLOGY LIMITED (GB) | 2010-01-19 | — | — | US | disclosed |
| US-20090209572-A1 | 36-Des(3-Methoxy-4-Hydroxycyclohexyl) 36-(3-Hydroxycycloheptyl) Derivatives of Rapamycin for the Treatment of Cancer and Other Disorders | BIOTICA TECHNOLOGY LIMITED (GB) | 2009-08-20 | — | — | US | disclosed |
| WO-2007135397-A1 | 36 -DES (3 -METHOXY-4 -HYDROXYCYCLOHEXYL) 36 - (3 -HYDROXYCYCLOHEPTYL) DERIVATIVES OF RAPAMYCIN FOR THE TREATMENT OF CANCER AND OTHER DISORDERS | BIOTICA TECHNOLOGY LIMITED (GB) | 2007-11-29 | — | — | WO | disclosed |
| EP-1856129-A1 | 39-DESMETHOXY DERIVATIVES OF RAPAMYCIN | Biotica Technology Limited (GB) | 2007-11-21 | — | — | EP | disclosed |
| US-7268144-B2 | Regiospecific synthesis of rapamycin 42-ester derivatives | WYETH (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268144-B2 | Regiospecific synthesis of rapamycin 42-ester derivatives | WYETH (US) | 2007-09-11 | — | — | US | disclosed |
| US-20070105888-A1 | 41-Methoxy isotope labeled rapamycin 42-ester | WYETH (US) | 2007-05-10 | — | — | US | disclosed |
| US-20070105888-A1 | 41-Methoxy isotope labeled rapamycin 42-ester | WYETH (US) | 2007-05-10 | — | — | US | disclosed |
| US-7202256-B2 | Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779 | WYETH (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202256-B2 | Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779 | WYETH (US) | 2007-04-10 | — | — | US | disclosed |
| WO-2006095185-A1 | 39-DESMETHOXY DERIVATIVES OF RAPAMYCIN | BIOTICA TECHNOLOGY LIMITED (GB) | 2006-09-14 | — | — | WO | disclosed |
| WO-2005105811-A1 | REGIOSPECIFIC SYNTHESIS OF RAPAMYCIN 42-ESTER DERIVATIVES | WYETH (US) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249415-A1 | Process for preparation of temsirolimus | RICTOR, MTOR, MLST8 | KCNA4 4251/4885KCNA1 4759/4885KCNAB1 3601/4885 |
| US-20100081682-A1 | 39-Desmethoxy Derivatives of Rapamycin | RICTOR, MTOR, MALT1 | KCNA4 4076/4885KCNA1 4123/4885KCNAB1 3311/4885 |
| US-20090209572-A1 | 36-Des(3-Methoxy-4-Hydroxycyclohexyl) 36-(3-Hydroxycycloheptyl) Derivatives of Rapamycin for the Treatment of Cancer and Other Disorders | MALT1, RICTOR, HGF | KCNA4 4327/4885KCNA1 4649/4885KCNAB1 3613/4885 |
| US-20070105888-A1 | 41-Methoxy isotope labeled rapamycin 42-ester | RICTOR, MTOR, RPTOR | KCNA4 4774/4885KCNA1 4731/4885KCNAB1 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.