Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 12/20 | 0.57 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | ATIC | P31939 | 3/20 | 0.47 |
| ▸ | FOLR1 | P15328 | 8/20 | 0.46 |
| ▸ | SLC46A1 | Q96NT5 | 5/20 | 0.46 |
| ▸ | FOLR2 | P14207 | 3/20 | 0.46 |
| ▸ | SLC19A1 | P41440 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7745908 | 0.87 | GART (0.75) | GARTATICFOLR1SLC46A1FOLR2 | |
| SCHEMBL9382790 | 0.86 | DHFR (0.52) | GARTDHFRATICFOLR1SLC46A1 | |
| SCHEMBL9382796 | 0.86 | DHFR (0.52) | GARTDHFRATICFOLR1SLC46A1 | |
| SCHEMBL6900553 | 0.80 | GART (0.47) | GARTDHFRATICFOLR1 | |
| SCHEMBL9380609 | 0.80 | DHFR (0.59) | GARTDHFRATICFOLR1SLC46A1 | |
| SCHEMBL9381796 | 0.80 | DHFR (0.59) | GARTDHFRATICFOLR1SLC46A1 | |
| SCHEMBL9383067 | 0.80 | DHFR (0.59) | GARTDHFRATICFOLR1SLC46A1 | |
| SCHEMBL1065440 | 0.80 | GART (0.62) | GARTATICFOLR1SLC46A1FOLR2 | |
| SCHEMBL20659947 | 0.80 | GART (0.62) | GARTATICFOLR1SLC46A1FOLR2 | |
| SCHEMBL14403392 | 0.80 | DHFR (0.59) | GARTDHFRATICFOLR1SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6426417-B1 | CYCLIZATION OF A CYANO-ESTER DERIVATIVE WITH 2,6-DIAMINO-6-HYDROXYPYRIMIDINE IN THE PRESENCE OF ACETIC ACID AND ACETONITRILE | ELI LILLY AND COMPANY | 2002-07-30 | — | — | US | disclosed |