Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058797 | 0.89 | TSHR (0.39) | CTSKTDP1TSHRPRKCAPRKCD | |
| SCHEMBL29287648 | 0.86 | CTSK (0.37) | CTSKTDP1CHRM1AKR1A1CHRM3 | |
| SCHEMBL31216727 | 0.86 | TSHR (0.44) | TSHRALDH1A1MAPTMAPK1FAAH | |
| SCHEMBL4365723 | 0.84 | GRIK1 (0.33) | CTSKTSHRGRIK1GRIK2CYP2C19 | |
| SCHEMBL17206246 | 0.83 | GRIK1 (0.38) | GRIK1GRIK2CYP2C19CPA1MAPT | |
| SCHEMBL1834073 | 0.81 | HDAC1 (0.46) | CTSKTDP1CHRM1AKR1A1CHRM3 | |
| SCHEMBL29091396 | 0.78 | CTSK (0.32) | CTSKPRKCAPRKCDALDH1A1 | |
| SCHEMBL348986 | 0.77 | PRKCA (0.47) | CTSKTDP1CHRM1AKR1A1CHRM3 | |
| SCHEMBL17464286 | 0.77 | TSHR (0.38) | CTSKTSHRALDH1A1MMP9 | |
| SCHEMBL28540645 | 0.76 | CTSK (0.31) | CTSKPRKCAPRKCDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192139-A1 | PREPARATION OF QUINOLINE-SUBSTITUTED CARBONATE AND CARBAMATE DERIVATIVES | Abbott Laboratories (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001000582-A1 | PREPARATION OF QUINOLINE-SUBSTITUTED CARBONATE AND CARBAMATE DERIVATIVES | ABBOTT LABORATORIES (US) | 2001-01-04 | — | — | WO | disclosed |