Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | PRKX | P51817 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 5/20 | 0.42 |
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739406 | 1.00 | ROCK2 (0.45) | ROCK2RPS6KA5RPS6KA4PRKACAMAPK1 | |
| SCHEMBL7740343 | 0.93 | PIN1 (0.49) | PIN1CTSLCTSSMMP8MAPT | |
| SCHEMBL7740348 | 0.93 | PIN1 (0.49) | PIN1CTSLCTSSMMP8MAPT | |
| SCHEMBL7739530 | 0.90 | PIN1 (0.44) | PIN1CTSLMMP8MAPTCTRB1 | |
| SCHEMBL7739536 | 0.90 | PIN1 (0.44) | PIN1CTSLMMP8MAPTCTRB1 | |
| SCHEMBL7740718 | 0.89 | KMT2A (0.43) | PIN1CTSLMMP8MAPTCTRB1 | |
| SCHEMBL7740902 | 0.89 | PIN1 (0.43) | PIN1CTSLMMP8MAPTCTRB1 | |
| SCHEMBL7741209 | 0.89 | PIN1 (0.43) | PIN1CTSLMMP8MAPTCTRB1 | |
| SCHEMBL7740721 | 0.89 | KMT2A (0.43) | PIN1CTSLMMP8MAPTCTRB1 | |
| SCHEMBL7740904 | 0.89 | PIN1 (0.43) | PIN1CTSLMMP8MAPTCTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |