Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 3/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740445 | 0.82 | MEN1 (0.39) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL7880767 | 0.81 | HPGD (0.36) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL25834987 | 0.76 | AR (0.36) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL27564256 | 0.75 | MEN1 (0.36) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL7880691 | 0.71 | AR (0.41) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL29570831 | 0.70 | L3MBTL1 (0.45) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL13277233 | 0.70 | L3MBTL1 (0.45) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL9677433 | 0.69 | CYP1A2 (0.48) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4MAPT | |
| SCHEMBL13277488 | 0.69 | CYP1A2 (0.41) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL31381636 | 0.69 | CYP1A2 (0.41) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1217928-C | Heterocyclic compound having NOS inhibitory action | CHUGAI SEIYAKA K K (JP) | 2005-09-07 | — | — | CN | disclosed |
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| CN-1280565-A | Heterocyclic compounds having NOS inhibitory activities | CHUGAI SEIYAKA K K (JP) | 2001-01-17 | — | — | CN | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |