Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739654 | 1.00 | POLB (0.47) | POLBGAALMNAMEN1ALDH1A1 | |
| SCHEMBL18572094 | 0.84 | ALDH1A1 (0.60) | POLBGAAMEN1ALDH1A1HPGD | |
| SCHEMBL2011835 | 0.84 | PPARA (0.55) | MEN1ALDH1A1HPGDKMT2AACE | |
| SCHEMBL13007476 | 0.84 | PPARA (0.55) | MEN1ALDH1A1HPGDKMT2AACE | |
| SCHEMBL13598111 | 0.84 | ADAMTS5 (0.50) | LMNAHPGDTDP1CA1CA2 | |
| SCHEMBL7742623 | 0.84 | ADAMTS5 (0.50) | LMNAHPGDTDP1CA1CA2 | |
| SCHEMBL7742625 | 0.84 | ADAMTS5 (0.50) | LMNAHPGDTDP1CA1CA2 | |
| SCHEMBL1376104 | 0.83 | MEN1 (0.48) | POLBGAAMEN1ALDH1A1HPGD | |
| SCHEMBL22612061 | 0.83 | MEN1 (0.48) | POLBGAAMEN1ALDH1A1HPGD | |
| SCHEMBL20630934 | 0.83 | MEN1 (0.48) | POLBGAAMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |