SCHEMBL7740128

SCHEMBL7740128

CCCC1CCC(C(=O)NCCCC(=O)O)CC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 1/20 0.49
GNAI3 P08754 2/20 0.46
GNAO1 P09471 2/20 0.46
GNAI1 P63096 2/20 0.46
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
TP53 P04637 2/20 0.43
LMNA P02545 2/20 0.43
ALDH1A1 P00352 1/20 0.43
MAPT P10636 1/20 0.42
PLA2G4A P47712 1/20 0.42
THRB P10828 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
ITGB3 P05106 2/20 0.41
ITGA2B P08514 2/20 0.41
EPHX2 P34913 1/20 0.41
GAA P10253 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7740129 1.00 NAAA (0.49) NAAAGNAI3GNAO1GNAI1CYP1A2
SCHEMBL7739487 0.87 NAAA (0.48) NAAAGNAI3GNAO1GNAI1CYP1A2
SCHEMBL7739482 0.87 NAAA (0.48) NAAAGNAI3GNAO1GNAI1CYP1A2
SCHEMBL2331473 0.85 EPHX2 (0.51) NAAAGNAI3GNAO1GNAI1KMT2A
SCHEMBL17359335 0.81 NAAA (0.49) NAAAGNAI3GNAO1GNAI1LMNA
SCHEMBL7739813 0.81 NAAA (0.46) NAAAGNAI3GNAO1GNAI1PLA2G4A
SCHEMBL7739816 0.81 NAAA (0.46) NAAAGNAI3GNAO1GNAI1PLA2G4A
SCHEMBL24098150 0.81 NAAA (0.68) NAAAGNAI3GNAO1GNAI1CYP1A2
Adipic Acid SCHEMBL15545686 0.80 AKR1B1 (0.56) LMNAALDH1A1MAPTMEN1KMT2A
SCHEMBL22134366 0.80 NAAA (0.45) NAAAGNAI3GNAO1GNAI1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6420427-B1 PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY ONO PHARMACEUTICAL CO., LTD. (JP) 2002-07-16 US claimed
EP-1024134-A1 AMINOBUTANOIC ACID DERIVATIVES ONO PHARMACEUTICAL CO., LTD. (JP) 2000-08-02 EP claimed
US-6420427-B1 PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY ONO PHARMACEUTICAL CO., LTD. (JP) 2002-07-16 US disclosed
EP-1024134-A1 AMINOBUTANOIC ACID DERIVATIVES ONO PHARMACEUTICAL CO., LTD. (JP) 2000-08-02 EP disclosed