Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 9/20 | 0.44 |
| ▸ | MAOA | P21397 | 7/20 | 0.44 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.44 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | NPY4R | P50391 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7541299 | 0.97 | KDM4E (0.56) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL7934318 | 0.93 | ALDH1A1 (0.51) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL1842451 | 0.90 | SIRT2 (0.46) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL29374941 | 0.90 | SIRT2 (0.46) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| Hydrochloric Acid SCHEMBL31754825 | 0.90 | SIRT2 (0.46) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| Hydrochloric Acid SCHEMBL1723683 | 0.90 | SIRT2 (0.46) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL11165484 | 0.89 | ALDH1A1 (0.50) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL11168545 | 0.88 | MEN1 (0.47) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL8550832 | 0.88 | MEN1 (0.46) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL4727432 | 0.87 | SIRT2 (0.49) | SIRT5SIRT1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000063350-A9 | CYSTEINE PROTEASE AND INHIBITORS FOR PREVENTION AND TREATMENT OF NEUROCYSTICEROCOSIS | UNIV GEORGIA RES FOUND (US) | 2002-06-13 | — | — | WO | disclosed |
| WO-2000063350-A2 | CYSTEINE PROTEASE AND INHIBITORS FOR PREVENTION AND TREATMENT OF NEUROCYSTICEROCOSIS | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2000-10-26 | — | — | WO | disclosed |