Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741141 | 0.92 | SIGMAR1 (0.56) | SIGMAR1TMEM97KMT2AMEN1ALDH1A1 | |
| SCHEMBL7742614 | 0.89 | SIGMAR1 (0.53) | SIGMAR1TMEM97KMT2AMEN1ALDH1A1 | |
| SCHEMBL7742570 | 0.82 | TMEM97 (0.57) | SIGMAR1TMEM97ALDH1A1ACHERAB9A | |
| SCHEMBL7740350 | 0.82 | CYP1A2 (0.47) | SIGMAR1TMEM97KMT2AMEN1ALDH1A1 | |
| SCHEMBL7741018 | 0.80 | TMEM97 (0.54) | SIGMAR1TMEM97KMT2AMEN1ALDH1A1 | |
| SCHEMBL7741193 | 0.80 | TMEM97 (0.47) | SIGMAR1TMEM97KMT2AMEN1ALDH1A1 | |
| SCHEMBL7741023 | 0.77 | TMEM97 (0.45) | SIGMAR1TMEM97KMT2AMEN1ALDH1A1 | |
| SCHEMBL8115911 | 0.77 | SIGMAR1 (0.54) | SIGMAR1TMEM97KMT2AACHEHTT | |
| SCHEMBL7742567 | 0.76 | TMEM97 (0.46) | SIGMAR1TMEM97KMT2AMEN1KDM4E | |
| SCHEMBL7739615 | 0.75 | MEN1 (0.43) | KMT2AMEN1ALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |