Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | FABP2 | P12104 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740350 | 0.85 | CYP1A2 (0.47) | MEN1KMT2ACYP1A2TSHRNFKB1 | |
| SCHEMBL5628818 | 0.77 | CYP1A2 (0.54) | MEN1KMT2ACYP1A2TSHRNFKB1 | |
| SCHEMBL7740225 | 0.75 | SIGMAR1 (0.54) | MEN1KMT2ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7741276 | 0.74 | CYP1A2 (0.54) | MEN1KMT2ACYP1A2TSHRNFKB1 | |
| SCHEMBL10287615 | 0.73 | CYP1A2 (0.55) | MEN1KMT2ACYP1A2TSHRNFKB1 | |
| SCHEMBL7741193 | 0.70 | TMEM97 (0.47) | MEN1KMT2ACYP1A2TSHRNFKB1 | |
| SCHEMBL10099552 | 0.69 | SMN1; SMN2 (0.67) | MEN1KMT2ACYP1A2TSHRNFKB1 | |
| SCHEMBL2669817 | 0.69 | GCGR (0.46) | MEN1KMT2ACYP1A2TSHRNFKB1 | |
| SCHEMBL7742567 | 0.68 | TMEM97 (0.46) | MEN1KMT2ASMN1; SMN2GAANPC1 | |
| SCHEMBL16380444 | 0.68 | TMEM97 (0.53) | MEN1KMT2ACYP1A2TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |