Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | MMP9 | P14780 | 4/20 | 0.46 |
| ▸ | MMP12 | P39900 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.34 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.34 |
| ▸ | PRKACA | P17612 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | GSK3A | P49840 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740331 | 0.88 | KDM1A (0.46) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7740338 | 0.88 | KDM1A (0.46) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7741007 | 0.83 | MMP2 (0.51) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7741003 | 0.83 | MMP2 (0.51) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7740017 | 0.81 | MMP2 (0.57) | MMP2MMP9MMP12ALDH1A1RAB9A | |
| SCHEMBL7740336 | 0.81 | MMP2 (0.57) | MMP2MMP9MMP12TSHRTAS1R3 | |
| SCHEMBL7740329 | 0.81 | MMP2 (0.57) | MMP2MMP9MMP12TSHRTAS1R3 | |
| SCHEMBL7740015 | 0.81 | MMP2 (0.57) | MMP2MMP9MMP12ALDH1A1RAB9A | |
| SCHEMBL7734696 | 0.81 | MMP2 (0.48) | MMP2MMP9MMP12TAS1R3TAS1R1 | |
| SCHEMBL7735094 | 0.81 | MMP2 (0.62) | MMP2MMP9MMP12L3MBTL1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | claimed |
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |