Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952426 | 0.78 | KDR (0.45) | KMT2AMEN1MAPTKDM4EHTT | |
| SCHEMBL3569657 | 0.72 | KDM4E (0.54) | KMT2AMEN1MAPTKDM4EHTT | |
| SCHEMBL5743583 | 0.71 | KDR (0.43) | KMT2AMEN1MAPTKDM4EHTT | |
| SCHEMBL6168326 | 0.69 | DHODH (0.58) | KMT2AMEN1MAPTKDM4EHTT | |
| SCHEMBL8304743 | 0.69 | KMT2A (0.46) | KMT2AMEN1MAPTKDM4EHTT | |
| SCHEMBL8298649 | 0.68 | KDM4E (0.60) | KMT2AMEN1MAPTKDM4EHTT | |
| SCHEMBL2122993 | 0.68 | ALDH1A1 (0.77) | KMT2AMEN1MAPTKDM4EHTT | |
| SCHEMBL7740395 | 0.67 | KDR (0.49) | KMT2AMEN1MAPTKDM4EHTT | |
| SCHEMBL11492008 | 0.67 | KDM4E (0.54) | KDM4EHTTTDP1ALDH1A1HPGD | |
| SCHEMBL8299609 | 0.65 | KDR (0.48) | KMT2AMEN1MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420359-B1 | 5,11-Dihydro-11-ethyl-5-methyl-8-(2-((1-oxido-4-quinolinyl)oxy)ethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one for example; antiviral agents for HIV infection | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2002-07-16 | — | — | US | disclosed |