Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744925 | 0.88 | POLB (0.47) | POLBKDM4ETOP2AMEN1KMT2A | |
| SCHEMBL29533972 | 0.79 | CHEK1 (0.47) | KCNH2MCHR1EGFR | |
| SCHEMBL6070377 | 0.79 | CHEK1 (0.47) | KCNH2MCHR1EGFR | |
| SCHEMBL5858823 | 0.75 | POLB (0.48) | POLBGAATOP2AKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL5859906 | 0.74 | POLB (0.47) | POLBGAAKMT2AALDH1A1HPGD | |
| SCHEMBL7746704 | 0.73 | TOP2A (0.55) | POLBKDM4EGAANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL30281924 | 0.73 | MAPT (0.51) | POLBSMN1; SMN2TOP2AMEN1KMT2A | |
| SCHEMBL7745480 | 0.73 | TOP2A (0.47) | POLBKDM4EGAATOP2AEP300 | |
| SCHEMBL7745467 | 0.72 | TOP2A (0.49) | POLBKDM4EGAATOP2AMEN1 | |
| SCHEMBL7740578 | 0.72 | TOP2A (0.46) | POLBKDM4EGAASMN1; SMN2TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |