Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7745480 | 0.87 | TOP2A (0.47) | TOP2APOLBKDM4EMEN1USP2 | |
| SCHEMBL7740578 | 0.86 | TOP2A (0.46) | TOP2APOLBKDM4EMEN1USP2 | |
| SCHEMBL7745824 | 0.83 | MEN1 (0.40) | POLBKDM4EMEN1USP2KMT2A | |
| SCHEMBL7740405 | 0.83 | KDM4E (0.43) | POLBKDM4EMEN1USP2KMT2A | |
| SCHEMBL7745460 | 0.83 | TSHR (0.61) | POLBKDM4EMEN1USP2KMT2A | |
| SCHEMBL7745216 | 0.82 | TSHR (0.50) | POLBKDM4EMEN1USP2KMT2A | |
| SCHEMBL7746704 | 0.82 | TOP2A (0.55) | TOP2APOLBKDM4EMEN1USP2 | |
| SCHEMBL7745475 | 0.81 | AKR1B1 (0.41) | POLBKDM4EMEN1USP2KMT2A | |
| SCHEMBL7745019 | 0.81 | KDM4E (0.47) | POLBKDM4EKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL10832034 | 0.80 | TOP2A (0.45) | TOP2APOLBKDM4EGUCY1B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |