Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | KCNK9 | Q9NPC2 | 6/20 | 0.61 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.60 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | PPARD | Q03181 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435795 | 0.85 | NR1H4 (0.64) | KMT2ARAB9ANPC1NR1H4MEN1 | |
| SCHEMBL29106507 | 0.83 | MEN1 (0.71) | KMT2ARAB9AKCNK9KCNK3NPC1 | |
| SCHEMBL17653723 | 0.82 | SLC7A5 (0.55) | KMT2ARAB9ANLRP3MEN1POLB | |
| SCHEMBL12314962 | 0.82 | KCNK9 (0.69) | KMT2ARAB9AKCNK9KCNK3NPC1 | |
| SCHEMBL30489996 | 0.82 | SLC7A5 (0.55) | KMT2ARAB9ANLRP3MEN1POLB | |
| SCHEMBL7338826 | 0.82 | SLC7A5 (0.58) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL8407573 | 0.81 | NR1H4 (0.50) | KMT2ARAB9ANPC1NR1H4HPSE | |
| SCHEMBL29106499 | 0.81 | SMN1; SMN2 (0.67) | KMT2ARAB9AKCNK9KCNK3NPC1 | |
| Hydrochloric Acid SCHEMBL8519670 | 0.81 | ITGB3 (0.60) | NR1H4HPSEPPARDSIRT1SMN1; SMN2 | |
| SCHEMBL3058933 | 0.81 | KMT2A (0.57) | KMT2ARAB9ANPC1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129075-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2001-09-05 | — | — | EP | claimed |
| WO-2000027820-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2000-05-18 | — | — | WO | claimed |
| EP-1129075-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027820-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2000-05-18 | — | — | WO | disclosed |