Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSG | P08311 | 5/20 | 0.40 |
| ▸ | CMA1 | P23946 | 4/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 4/20 | 0.36 |
| ▸ | MMP9 | P14780 | 4/20 | 0.36 |
| ▸ | MMP12 | P39900 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740986 | 1.00 | CTSG (0.40) | CTSGCMA1PRSS1CTRB1MMP2 | |
| SCHEMBL7741000 | 0.92 | CTSG (0.44) | CTSGCMA1PRSS1CTRB1 | |
| SCHEMBL7740994 | 0.92 | CTSG (0.44) | CTSGCMA1PRSS1CTRB1 | |
| SCHEMBL7739337 | 0.91 | MEN1 (0.40) | CTSGCMA1PRSS1CTRB1MMP2 | |
| SCHEMBL7739341 | 0.91 | MEN1 (0.40) | CTSGCMA1PRSS1CTRB1MMP2 | |
| SCHEMBL7742558 | 0.90 | MEN1 (0.41) | CTSGCMA1PRSS1CTRB1MMP2 | |
| SCHEMBL7742562 | 0.90 | MEN1 (0.41) | CTSGCMA1PRSS1CTRB1MMP2 | |
| SCHEMBL7741174 | 0.84 | MEN1 (0.38) | CTSGCMA1PRSS1CTRB1MMP2 | |
| SCHEMBL7741183 | 0.84 | MEN1 (0.38) | CTSGCMA1PRSS1CTRB1MMP2 | |
| SCHEMBL6300445 | 0.84 | MEN1 (0.40) | CTSGCMA1PRSS1CTRB1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | claimed |
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |