Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 10/20 | 0.61 |
| ▸ | ABCC1 | P33527 | 6/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7917543 | 0.86 | ABCB1 (0.79) | ABCB1ABCC1MAPK1MAPTNPC1 | |
| SCHEMBL8010707 | 0.76 | ABCB1 (0.77) | ABCB1ABCC1MAPK1MEN1KMT2A | |
| SCHEMBL7919608 | 0.75 | ABCB1 (0.78) | ABCB1ABCC1MAPK1MEN1KMT2A | |
| SCHEMBL20356916 | 0.74 | ABCB1 (0.79) | ABCB1ABCC1MAPK1MAPTNPC1 | |
| SCHEMBL29375530 | 0.72 | NPC1 (0.73) | ABCB1ABCC1MAPK1MAPTNPC1 | |
| SCHEMBL16179942 | 0.72 | ABCC1 (1.00) | ABCB1ABCC1 | |
| SCHEMBL6705974 | 0.71 | NPC1 (0.70) | ABCB1ABCC1MAPK1MAPTNPC1 | |
| SCHEMBL6707064 | 0.70 | MAPT (0.77) | ABCB1ABCC1MAPK1MAPTNPC1 | |
| SCHEMBL16179746 | 0.70 | ABCB1 (1.00) | ABCB1ABCC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7245174 | 0.69 | NPC1 (0.76) | ABCB1ABCC1MAPK1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420410-B1 | ADMINISTERING N,N'-SUBSTITUTED BENZIMIDAZOL-2-ONES TO INDUCE APOPTOSIS IN NEOPLASTIC CELLS BUT NOT NORMAL CELLS; ANTICANCER, ANTITUMOR AGENT | CELL PATHWAYS, INC. | 2002-07-16 | — | — | US | disclosed |