Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 15/20 | 0.77 |
| ▸ | ABCC1 | P33527 | 11/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7917543 | 0.88 | ABCB1 (0.79) | ABCB1ABCC1MEN1KMT2AMAPK1 | |
| SCHEMBL7919608 | 0.87 | ABCB1 (0.78) | ABCB1ABCC1MEN1KMT2AMAPK1 | |
| SCHEMBL16179942 | 0.84 | ABCC1 (1.00) | ABCB1ABCC1 | |
| SCHEMBL16180274 | 0.80 | ABCB1 (1.00) | ABCB1ABCC1MAPK1ALDH1A1 | |
| SCHEMBL16179746 | 0.79 | ABCB1 (1.00) | ABCB1ABCC1 | |
| SCHEMBL8024676 | 0.78 | MEN1 (0.77) | ABCB1ABCC1MEN1KMT2AMAPK1 | |
| SCHEMBL27657641 | 0.78 | HCAR3 (0.74) | ABCB1ABCC1MAPK1ALDH1A1 | |
| SCHEMBL16180104 | 0.77 | ABCB1 (1.00) | ABCB1ABCC1MAPK1ALDH1A1 | |
| SCHEMBL8901923 | 0.77 | ABCB1 (0.46) | ABCB1ABCC1MEN1KMT2AMAPK1 | |
| SCHEMBL20356916 | 0.76 | ABCB1 (0.79) | ABCB1ABCC1MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030992-A | ANTAGONISTS FOR THE BINDING OF NEUROKININ-2 RECEPTOR; SLEEP DISORDERS; BENZIMIDES, 2- OR 3-ALKOXYBENZIMIDES AND 2,3-DIALKOXYBENZIMIDES | ELI LILLY AND COMPANY (US) | 2000-02-29 | — | — | US | disclosed |
| US-6025379-A | A SUBSTITUTED BENZIMIDAZOLE, TACHYKININ RECEPTOR ANTAGONISTS, | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |
| US-5552426-A | NERVOUS SYSTEM DISORDERS USING IMIDAZOLE DERIVITIVES | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0694535-A1 | Non-peptidyl tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-01-31 | — | — | EP | disclosed |