Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7738452 | 1.00 | L3MBTL1 (0.35) | L3MBTL1ALDH1A1SMN1; SMN2EPHX1EPHX2 | |
| Bicarbonate SCHEMBL7737584 | 0.95 | L3MBTL1 (0.39) | L3MBTL1ALDH1A1SMN1; SMN2EPHX1EPHX2 | |
| Bicarbonate SCHEMBL7737748 | 0.95 | L3MBTL1 (0.39) | L3MBTL1ALDH1A1SMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL7738454 | 0.90 | L3MBTL1 (0.33) | L3MBTL1ALDH1A1SMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL7608394 | 0.78 | LMNA (0.33) | SMN1; SMN2THRB | |
| Bicarbonate SCHEMBL7739242 | 0.70 | LMNA (0.34) | — | |
| SCHEMBL21826053 | 0.68 | MAPK1 (0.32) | SMN1; SMN2 | |
| SCHEMBL31631359 | 0.67 | MAPK1 (0.31) | SMN1; SMN2 | |
| SCHEMBL31631378 | 0.67 | MAPK1 (0.31) | SMN1; SMN2 | |
| SCHEMBL31631350 | 0.67 | MAPK1 (0.31) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410748-B1 | Alicycli c group-containing monomer | KABUSHIKI KAISHA TOSHIBA (JP) | 2002-06-25 | — | — | US | disclosed |
| US-6291129-B1 | LIGHT SENSITIVE ELEMENT WITH UNSATURATED POLYMERS | KABUSHIKI KAISHA TOSHIBA (JP) | 2001-09-18 | — | — | US | disclosed |