SCHEMBL7741249

SCHEMBL7741249

C[Si](C)(C)c1ccccc1.OBO

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.46
ESR2 Q92731 1/20 0.46
MAPT P10636 1/20 0.41
NR1H2 P55055 3/20 0.38
NR1H3 Q13133 3/20 0.38
ACHE P22303 2/20 0.35
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
TDP1 Q9NUW8 2/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
GLA P06280 1/20 0.32
CA3 P07451 1/20 0.32
CA4 P22748 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32
LMNA P02545 1/20 0.32
TSHR P16473 1/20 0.32
ALOX12 P18054 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL92396 0.88 ESR1 (0.48) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL28415835 0.85 ESR1 (0.46) ESR1ESR2MAPTNR1H2NR1H3
Phosphine SCHEMBL28991719 0.85 ESR1 (0.46) ESR1ESR2MAPTNR1H2NR1H3
Methane SCHEMBL28815257 0.85 ESR1 (0.46) ESR1ESR2MAPTNR1H2NR1H3
Ethylene SCHEMBL25342007 0.82 ESR1 (0.44) ESR1ESR2MAPTNR1H2NR1H3
Formaldehyde SCHEMBL28845505 0.80 ESR1 (0.42) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL2452306 0.78 ESR1 (0.46) ESR1ESR2MAPTNR1H2NR1H3
Chlorobenzene SCHEMBL29067378 0.76 TSHR (0.58) ESR1ESR2MAPTNR1H2NR1H3
Bromobenzene SCHEMBL29151666 0.76 ALDH1A1 (0.58) ESR1ESR2MAPTNR1H2NR1H3
SCHEMBL10319120 0.74 ESR1 (0.43) ESR1ESR2MAPTNR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6312839-B1 ALKYL- OR TRIALKYLSILYL-SUBSTITUTED 1-FLUORENYL-1,2-BIS(P-BIPHENYL)ETHYLENE COMPOUNDS SAMSUNG DISPLAY DEVICES CO., LTD. (KR) 2001-11-06 US disclosed