Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559034 | 0.79 | CHRM5 (0.38) | HRH3HSD17B10POLBSMN1; SMN2CXCR4 | |
| SCHEMBL1082345 | 0.74 | HSD17B10 (0.38) | HRH3HSD17B10POLBSMN1; SMN2CXCR4 | |
| SCHEMBL1705461 | 0.71 | CHRM5 (0.42) | HSD17B10POLBSMN1; SMN2CHRM5CHRM3 | |
| SCHEMBL9261652 | 0.70 | — | — | |
| SCHEMBL11393659 | 0.70 | — | — | |
| Urea SCHEMBL10753125 | 0.69 | NPC1 (0.39) | HRH3HSD17B10CHRM5CHRM3SIGMAR1 | |
| SCHEMBL22165291 | 0.68 | CHRM5 (0.36) | HSD17B10POLBSMN1; SMN2CHRM5CHRM3 | |
| SCHEMBL1234464 | 0.67 | SIGMAR1 (0.38) | HRH3HSD17B10POLBSMN1; SMN2CXCR4 | |
| SCHEMBL861272 | 0.67 | SMN1; SMN2 (0.35) | HRH3HSD17B10POLBSMN1; SMN2CXCR4 | |
| SCHEMBL175418 | 0.67 | POLB (0.35) | HRH3HSD17B10POLBSMN1; SMN2CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423725-B1 | ANALGESICS | PFIZER INC | 2002-07-23 | — | — | US | disclosed |
| EP-1049689-A1 | 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER INC. (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999036421-A1 | 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-22 | — | — | WO | disclosed |