Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20120105 | 0.86 | ALDH1A1 (0.48) | TAAR1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL56003 | 0.80 | L3MBTL1 (0.57) | CA12CA2CA9TAAR1MEN1 | |
| SCHEMBL196635 | 0.78 | KMT2A (0.49) | CA12CA2CA9TAAR1MEN1 | |
| SCHEMBL1547824 | 0.78 | KMT2A (0.49) | CA12CA2CA9TAAR1MEN1 | |
| SCHEMBL2201285 | 0.78 | CA12 (0.50) | CA12CA2CA9TAAR1MEN1 | |
| SCHEMBL5928168 | 0.78 | KDM4E (0.44) | TAAR1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL11044440 | 0.78 | CA12 (0.50) | CA12CA2CA9TAAR1MEN1 | |
| SCHEMBL26081358 | 0.77 | ALDH1A1 (0.52) | HTTALDH1A1TSHRKDM4E | |
| SCHEMBL11973878 | 0.77 | KMT2A (0.47) | CA12CA2CA9TAAR1MEN1 | |
| SCHEMBL11973371 | 0.77 | KMT2A (0.47) | CA12CA2CA9TAAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520226-B2 | Halogen scavenger composition | ST CHEMICAL CO LTD (JP) | 2000-10-11 | — | — | EP | claimed |
| EP-2989096-B1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEIGENE LTD (KY) | 2019-04-10 | — | — | EP | disclosed |
| CN-105102452-B | The ketones derivant of 5 (base of 3,5 dimethyl isoxazole 4) indoline 2 of substitution | 百济神州有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-103124717-B | The method that selectivity obtains N methyl paraphenetidines | 创新企业泰克诺普阮姆有限责任公司 | 2018-01-02 | — | — | CN | disclosed |
| US-9827226-B2 | Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones | BEIGENE, LTD. (KY) | 2017-11-28 | — | — | US | disclosed |
| US-20170027912-A1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEONE MEDICINES I GMBH (CH) | 2017-02-02 | — | — | US | disclosed |
| EP-2989096-A1 | SUBSTITUTED5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BeiGene, Ltd. (KY) | 2016-03-02 | — | — | EP | disclosed |
| WO-2014173241-A1 | SUBSTITUTED5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEIGENE, LTD. (GB) | 2014-10-30 | — | — | WO | disclosed |
| US-6423799-B1 | IRRADIATION | BAYER AG (DE) | 2002-07-23 | — | — | US | disclosed |
| US-5190640-A | Sweetening sour oils and gases | BAKER HUGHES INCORPORATED (US) | 1993-03-02 | — | — | US | disclosed |
| US-4786595-A | HYDROPHILIC BINDER WITH NONIONIC SURFACTANT, MEDICAL DIAGNOSIS | FUJI PHOTO FILM CO., LTD. (JP) | 1988-11-22 | — | — | US | disclosed |
| US-4503145-A | DIAGNOSIS OF LIVER DISORDERS | FUJI PHOTO FILM CO., LTD. (JP) | 1985-03-05 | — | — | US | disclosed |
| US-4478942-A | CATIONIC DYE BOUND TO ANIONIC POLYMER FOR ASSAY OF HYDROGEN PEROXIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1984-10-23 | — | — | US | disclosed |
| US-4418037-A | PYROGALLOL DERIVATIVE STORAGE STABILIZER | FUJI PHOTO FILM CO., LTD. (JP) | 1983-11-29 | — | — | US | disclosed |
| US-4062893-A | SULFURIC ACID CATALYST | NEW JAPAN CHEMICAL COMPANY, LIMITED (JA) | 1977-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170027912-A1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BRD4, BRPF3, BRD3 | CA12 4752/4885CA2 4458/4885CA9 4597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.