Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MPO | P05164 | 3/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6440646 | 0.90 | GRIK1 (0.44) | KDM4EALDH1A1HPGDHSD17B10GRIK1 | |
| SCHEMBL7642079 | 0.86 | GRIK1 (0.47) | KDM4EALDH1A1HPGDHSD17B10GRIK1 | |
| SCHEMBL7741945 | 0.86 | MPO (0.54) | KDM4EALDH1A1HPGDHSD17B10GRIK1 | |
| SCHEMBL7617161 | 0.86 | SMN1; SMN2 (0.45) | KDM4EALDH1A1HPGDHSD17B10AKR1C3 | |
| SCHEMBL7621277 | 0.84 | MEN1 (0.41) | KDM4EALDH1A1HPGDHSD17B10GRIK1 | |
| SCHEMBL5606524 | 0.83 | CES2 (0.50) | KDM4EALDH1A1MEN1KMT2ASRD5A2 | |
| SCHEMBL7613082 | 0.83 | MPO (0.51) | KDM4EALDH1A1HPGDHSD17B10GRIK1 | |
| SCHEMBL7609229 | 0.83 | GRIK1 (0.46) | KDM4EALDH1A1HPGDHSD17B10GRIK1 | |
| SCHEMBL7613732 | 0.82 | AKR1C3 (0.54) | KDM4EAKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL28217598 | 0.82 | PTGIR (0.46) | MEN1KMT2ASRD5A2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417393-B1 | TREATMENT OF SICKLE-CELL ANEMIA, BRAIN EDEMA FROM TUMORS OR ISCHEMIA, DIARRHEA, AND GLAUCOMA; HYPOTENSIVE, WOUND HEALING, ANTIINFLAMMATORY AND ANTIALLERGEN AGENTS | NEUROSEARCH A/S (DK) | 2002-07-09 | — | — | US | disclosed |
| EP-0906273-A1 | PHENYL DERIVATIVES CONTAINING AN ACIDIC GROUP, THEIR PREPARATION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045400-A1 | PHENYL DERIVATIVES CONTAINING AN ACIDIC GROUP, THEIR PREPARATION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 1997-12-04 | — | — | WO | disclosed |