Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14142265 | 0.91 | DDB1 (0.42) | DDB1CRBNCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14294652 | 0.91 | DDB1 (0.42) | DDB1CRBNCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22143891 | 0.91 | DDB1 (0.45) | DDB1CRBNCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL29360415 | 0.90 | DDB1 (0.44) | DDB1CRBNCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2919213 | 0.85 | CYP3A4 (0.39) | DDB1CRBNCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2915694 | 0.85 | CYP3A4 (0.39) | DDB1CRBNCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14142266 | 0.85 | KMT2A (0.43) | DDB1CRBNKMT2AMEN1ATM | |
| SCHEMBL22144163 | 0.84 | CYP3A4 (0.44) | DDB1CRBNCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL24921828 | 0.84 | DDB1 (0.41) | DDB1CRBNCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13167677 | 0.83 | NPC1 (0.41) | DDB1CRBNCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417197-B1 | PRODRUGS FORMED WITH ESTERIFICATION AND ACIDIFICATION | GRUENENTHAL GMBH (DE) | 2002-07-09 | — | — | US | disclosed |