Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 6/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22143891 | 0.91 | DDB1 (0.45) | DDB1CRBNCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7742010 | 0.90 | DDB1 (0.43) | DDB1CRBNSCN9ACYP3A4CYP2D6 | |
| SCHEMBL22143936 | 0.85 | DDB1 (0.44) | DDB1CRBNSTAT3 | |
| SCHEMBL22144163 | 0.85 | CYP3A4 (0.44) | DDB1CRBNCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14142265 | 0.82 | DDB1 (0.42) | DDB1CRBNSCN9ACYP3A4CYP2D6 | |
| SCHEMBL14294652 | 0.82 | DDB1 (0.42) | DDB1CRBNSCN9ACYP3A4CYP2D6 | |
| SCHEMBL24421051 | 0.81 | DDB1 (0.47) | DDB1CRBNADRA1DADRA1AADRA1B | |
| SCHEMBL29614631 | 0.81 | DDB1 (0.47) | DDB1CRBNADRA1DADRA1AADRA1B | |
| SCHEMBL22144164 | 0.81 | DDB1 (0.42) | DDB1CRBNSCN9ASTAT3 | |
| SCHEMBL14294761 | 0.80 | DDB1 (0.43) | DDB1CRBNADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114341128-B | Bifunctional protein degradation targeting chimeric compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-114341128-A | Bifunctional protein degradation targeting chimera compound and preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-04-12 | — | — | CN | disclosed |
| WO-2022017442-A1 | BIFUNCTIONAL PROTEIN DEGRADATION-TARGETED CHIMERA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICINAL USE THEREOF | 恩瑞生物医药科技（上海）有限公司 | 2022-01-27 | — | — | WO | disclosed |