SCHEMBL7742748

SCHEMBL7742748

COC(C)Nc1ccccc1/C=C/C(=O)N(C[C]=O)C(=O)c1ccccn1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SNCA P37840 5/20 0.39
ALDH1A1 P00352 5/20 0.34
KDM4E B2RXH2 4/20 0.34
NPC1 O15118 6/20 0.33
RAB9A P51151 4/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
MAPT P10636 3/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
GAA P10253 2/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
PKM P14618 1/20 0.33
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
GRM4 Q14833 1/20 0.32
KRAS P01116 1/20 0.31
TRPM8 Q7Z2W7 1/20 0.31
HTT P42858 1/20 0.31
GRM5 P41594 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7742937 0.85 SNCA (0.40) SNCAALDH1A1KDM4ENPC1RAB9A
SCHEMBL7746871 0.84 NFE2L2 (0.34) ALDH1A1KDM4ERAB9AMAPTSMN1; SMN2
SCHEMBL7748576 0.82 NFE2L2 (0.33) ALDH1A1NPC1L3MBTL1MAPTSMN1; SMN2
SCHEMBL7742888 0.82 ALDH1A1 (0.40) ALDH1A1KDM4ENPC1RAB9AL3MBTL1
SCHEMBL7750148 0.72 ALDH1A1 (0.37) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL7749800 0.71 ALDH1A1 (0.34) ALDH1A1NPC1RAB9AL3MBTL1MAPT
SCHEMBL7747068 0.69 BTN3A1 (0.33) LMNAHTT
SCHEMBL7747277 0.68 KDM4E (0.38) ALDH1A1KDM4ENPC1MAPTGAA
SCHEMBL7746941 0.68 NFE2L2 (0.36) SNCAALDH1A1KDM4EMAPTSMN1; SMN2
SCHEMBL7742792 0.68 KDM4E (0.37) SNCAALDH1A1KDM4ENPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0622361-B1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 2001-10-04 EP disclosed
US-6194396-B1 ANTIALLERGENS; ANTIINFLAMMATION AGENTS; AUTOIMMUNE DISEASE; ANTISHOCK AGENTS; ANALGESICS; E.G., A 4 OR 7-PHENYLALKYLENE-OXYBENZIMIDAZOLE UNSUBSTITUTED OR SUBSTITUTED IN THE 1,2,3-POSITION WITH AN OXY, AMINO AND/OR THIO GROUP FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-02-27 US disclosed
US-6169095-B1 FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES IN THE EYE, SUCH AS ALLERGY, INFLAMMATION AND PAIN OF THE EYE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
US-6083961-A FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES SUCH AS ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-07-04 US disclosed
US-5922711-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISEASES, SHOCK OR ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-07-13 US disclosed
US-5750699-A HALOGENATING OF CORRESPONDING COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-05-12 US disclosed
US-5708173-A PREPARATION OF SUBSTITUTED QUINOLINE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-01-13 US disclosed
EP-0774462-A1 HETEROCYCLIC COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-05-21 EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
US-5563162-A CAN BE ADMINISTERD FOR THE TREATMENT OF ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASES, SHOCK OR PAIN IN ANIMALS AND HUMANS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-10-08 US disclosed
EP-0622361-A1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-11-02 EP disclosed