Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 7/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | LIG1 | P18858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743008 | 1.00 | CXCR2 (0.43) | CXCR2CXCR1MAPTALDH1A1LMNA | |
| SCHEMBL7751145 | 0.87 | CHRNB2 (0.43) | MAPTALDH1A1LMNAPOLBPKM | |
| SCHEMBL7751139 | 0.87 | CHRNB2 (0.43) | MAPTALDH1A1LMNAPOLBPKM | |
| SCHEMBL6818586 | 0.83 | CXCR2 (0.46) | CXCR2CXCR1MAPTALDH1A1LMNA | |
| SCHEMBL7737472 | 0.81 | CXCR2 (0.67) | CXCR2CXCR1MAPTALDH1A1LMNA | |
| SCHEMBL7938088 | 0.81 | CXCR2 (0.67) | CXCR2CXCR1MAPTALDH1A1LMNA | |
| SCHEMBL6818508 | 0.81 | CXCR2 (0.44) | CXCR2CXCR1MAPTALDH1A1LMNA | |
| SCHEMBL6818505 | 0.81 | CXCR2 (0.44) | CXCR2CXCR1MAPTALDH1A1LMNA | |
| SCHEMBL7751186 | 0.75 | ALDH1A1 (0.36) | CXCR2CXCR1MAPTALDH1A1LMNA | |
| SCHEMBL6818590 | 0.74 | CXCR2 (0.44) | CXCR2CXCR1ALDH1A1POLBLIG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957907-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248785-B1 | CHEMOKINE SENSITIVE DISEASE | SMITHKLINE BEECHAM CORPORATION | 2001-06-19 | — | — | US | disclosed |
| EP-0957907-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998005317-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-12 | — | — | WO | disclosed |